Welcome to The Department of Integrative Physiology

The Department of Physiology has been an integral part of the University of Split School of Medicine (USSM) since its establishment in 1997.  Since then it has grown into a prominent centre of scientific excellence within the region with a substantial scientific production, developed international ties and a growing number of incoming researchers. The main activities within the Department include basic research and teaching of the medical students and clinical practitioners.

Laboratories for Clinical and Exercise Physiology are equipped with instruments for non-invasive evaluation of cardiopulmonary system in humans at rest and during exercise. They include spiroergometry, ultrasonic scanners with different tissue and vascular probes, respiratory mass spectrometer, transcranial Doppler, various ergometers and different analytical instruments (lactate, blood gas machine, cooximeter, blood count). In addition to the listed methodology, several animal models of cardiovascular disease are being established at the Laboratory for Cellular Physiology that will enable the investigation of the pathological processes at the subcellular and molecular level.

 

Note: In case you are interested in our teaching activities, please refer to a specialized web page (in Croatian only).

 

News and Events

Posted on December 6st, 2011

Review article "Impact of breath-holding on cardiovascular respiratory and cerebrovascular health" has been accepted for publication in Sports Medicine journal.

 

Posted on October 12st, 2011

Scientific publication "Determinants of Arterial Gas Embolism after SCUBA Diving" has been accepted for publication in Journal of Applied Physiology.

 

Posted on October 1st, 2011

Scientific publication "Observation of increased venous gas emboli after wet dives compared to dry dives" has been accepted for publication in Diving and Hyperbaric Medicine journal.

 

Posted on September 18th, 2011

Scientific publication "Effects of successive air and nitrox dives on human vascular function" has been accepted for publication in European Journal of Applied Physiology.

 

Posted on July 12th, 2011

Our Ph.D. candidate Toni Breskovic, M.D., under mentorship of Zeljko Dujic, M.D., Ph.D., successfully defended his Ph.D. thesis entitled "Sensitivity of peripheral chemoreceptors and activation pattern of sympathetic nervous system during breath-holding at different lung volumes in apnea divers".

 

Posted on June 27th, 2011

Scientific publication "Cardiovascular changes during underwater static and dynamic breath-hold dives in trained divers" has been accepted for publication in Journal of Applied Physiology journal.

 

Posted on May 18th, 2011

Scientific publication "Recruitment pattern of sympathetic neurons during breath-holding at different lung volumes in apnea divers and controls" has been accepted for publication in Autonomic Neuroscience: Basic and Clinical journal.

 

Posted on April 15th, 2011

Scientific publication "Cardiac Magnetic Resonance Imaging during Pulmonary Hyperinflation in Apnea Divers" has been accepted for publication in Medicine & Science in Sports and Exercise journal.

 

Posted on February 4th, 2011

Scientific publication "Breath hold diving: In vivo model of the brain survival response in man?" has been accepted for publication in Medical Hypotheses journal.

 

Posted on November 22nd, 2010

2nd International Symposium on Hypertension - Translational Medicine in Hypertension was held in Osijek, Croatia from November 17-21st 2010. Dr Dujic presented findings about physiological adaptations during breath hold in the laboratiry conditions. The talk was entitled "Cardiopulmonary effects of breath hold" and can be find here.

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Posted on October 29th, 2010

Scientific publication "Venous and arterial bubbles at rest after no-decompression air dives" has been accepted for publication in Medicine & Science in Sports & Exercise journal.

 

Posted on October 7st, 2010

Scientific publication "Sympathetic neural activation: an ordered affair" has been accepted for publication in The Journal of Physiology journal.

 

Posted on October 1st, 2010

Scientific publication "No-decompression air dive and ultrasound lung comets" has been accepted for publication in Aviation, Space, and Environmental Medicine journal.

 

Posted on September 22nd, 2010

Scientific publication "Sympathetic and cardiovascular responses to glossopharyngeal insufflation in trained apnea divers" has been accepted for publication in Journal of Applied Physiology journal.

 

Posted on September 3rd, 2010

Scientific publication "Ventilatory restraint of sympathetic activity during chemoreflex stress" has been accepted for publication in The American Journal of Physiology - Regulatory, Integrative and Comparative Physiology journal.

 

Posted on September 2nd, 2010

Scientific publication "High incidence of venous and arterial gas emboli at rest after trimix diving without protocol violations" has been accepted for publication in Journal of Applied Physiology journal.

 

Posted on August 9th, 2010

Drs. Dujic and Ljubkovic participated at the Annual workshop entitled Undersea Medicine Program Review in Seattle, WA, USA. The conference was organized by the Office of Naval Research and the US Navy, which also in great part sponsored the attendance of Drs. Dujic and Ljubkovic. During the Meeting, Dr. Dujic gave a talk about the research performed by our research group and some of the recent findings from our laboratory. During the course of the Workshop, they also had a chance to hold lots of excellent discussions and make plans for future collaboration with fellow scientists from the similar field of interest.

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Posted on July 15th, 2010

Scientific publication "Successive deep dives impair endothelial function and enhance oxidative stress in man" has been accepted for publication in Clinical Physiology and Functional Imaging journal.

 

Posted on July 9th, 2010

Scientific publication "Immersion prior to dry simulated dive reduces cardiomyocyte function and increases mortality after decompression" has been accepted for publication in Journal of Applied Physiology journal.

 

Posted on June 10th, 2010

Scientific publication "Glossopharyngeal insufflation induces cardioinhibitory syncope in apnea divers" has been accepted for publication in Clinical Autonomic Research journal.

 

Posted on June 8th, 2010

Our Ph.D. candidate Duska Glavas, M.D., M.Sc., under mentorship of Zeljko Dujic, M.D., Ph.D., successfully defended her Ph.D. thesis entitled "Effect of scuba diving on appearance of gas bubbles in recreational divers and persons with chronic spinal cord injury".

 

Posted on May 13th, 2010

Scientific publication "Autonomic and cardiovascular responses to chemoreflex stress in apnoea divers" has been accepted for publication in Autonomic Neuroscience: Basic and Clinical journal.

 

Posted on May 5th, 2010

Researchers from our Department visited Cleveland Clinic Foundations where they were hosted by Dr. Mladen Golubic from the Wellness Institute. During the visit to the CCF, Dr. Dujic gave a talk about the activities of the group and all members had a chance to meet a number of experts from the Institute. We were also introduced to the Healthy lifestyle program offered at the Institute named “Lifestyle 180® which is becoming more and more popular nationwide. The program is headed by Dr. Mike Roizen, who gave us an interesting overview on the main ideas and his vision of the program and offered help in organizing similar kind of activity at the Medical School of the Hospital in Split.

 

Posted on May 3rd, 2010

In period from April 29th till May 2nd researchers from our Department visited Neurovascular Research Laboratory at School of Kinesiology, University of Western Ontario, London, ON, Canada. It was an opportunity to meet with our collaborators Drs. J. Kevin Shoemaker and Craig D. Steinbeck. During four day long visit we worked on final drafting of the manuscript whose data were gathered in previous collaborative study in Split (June 2009). Furthermore, new future goals for joint collaboration and objectives for upcoming studies were set, together with plans for submission of future collaborative grants.

 

Posted on April 30th, 2010

From April 24th – 29th members of our Department participated at the international meeting Experimental Biology in Anaheim, CA, USA. The data from our group have been presented in the form of three poster presentations and one oral presentation, held by Dr. Breskovic. During the stay in Anaheim, we had a chance to meet with colleagues from other groups we collaborate with and set the base for the joint research study with Dr. Bruce Johnson from Mayo clinic which is planned for the fall 2010.

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Posted on April 12th, 2010

Scientific grant entitled "The application of latest advances in Doppler echocardiography in clinical and experimental echocardiology" submitted by our assistant professor Darija Bakovic, was accepted for financing by the Unity Through Knowledge Fund. More information about this grant can be found on our Projects page.

 

Posted on March 30th, 2010

Scientific publication "A novel wearable apnea dive computer for continuous plethysmographic monitoring of oxygen saturation and heart rate" has been accepted for publication in Diving and Hyperbaric Medicine journal.

 

Posted on March 10th, 2010

Scientific publication "Parameter Estimation of the Copernicus Decompression Model Using Non-linear Optimization" has been accepted for publication in Medical & Biological Engineering & Computing journal.

 

Posted on March 8th, 2010

Our visiting professor Hubert V. Forster held a final physiology course lecture to the 2nd year medical students. The topic of the lecture was The Physiological Properties of The Respiratory System. In the second part of his lecture, Professor Forster presented several new insights in central regulation of breathing which resulted from the recent scientific research of his group. Aside from just providing the new information about the respiratory physiology, the lecture served as an excellent example for presenting to students the intensive pace of changes in comprehension of human body function and limitations of textbooks as the only source of knowledge.

Afterwards, Professor Forster participated in our weekly journal club. The center of attention involved one of his recent review articles discussing the latest findings about the influence of peripheral and central chemoreceptors on central regulation of breathing.

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Posted on February 18th, 2010

Scientific publication "Ultrasonic evidence of acute interstitial lung edema after SCUBA diving is resolved within 2-3 hours" has been accepted for publication in Respiratory Physiology & Neurobiology journal.

 

Posted on February 10th, 2010

Dr. Neal Pollock from The Duke Center for Hyperbaric Medicine and Environmental Physiology (Duke University, Durham, NC) visited our group for one day. During his visit dr. Pollock presented several segments of his research involving use of ultrasound in decompression research. You can download the presentation here. Dr. Pollock’s visit served as an exceptional occasion for better acquaintance with the members of our staff and presentation of our findings in a field of SCUBA diving. The meeting provoked intensive discussion for possible future collaboration and joint studies.

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Posted on February 8th, 2010

Our two staff members drs. Marko Ljubkovic and Toni Breskovic participated in the 8th International Symposium Diving AST 2010 organized by IAHD-Adriatic. The symposium was held in beautiful surroundings of Slovenian countryside in Zreče, Slovenia on 5th and 6th of February.

Dr. Breskovic presented recent published work by our group on a topic of cardiovascular regulation during maximal apneas. You can download the presentation here. Dr. Ljubkovic was a chairman on the "Apnea" session.

Except for the presentation of own work, the symposium served as an excellent opportunity to meet and discuss with other scientists, industry representatives and divers about various topics regarding apnea, SCUBA and technical diving.

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Posted on January 25th, 2010

Redesigned web pages of our Department are finally operative! It is our idea to use them for presentation of our scientific activities. Additionally, we plan to maintain them only in English thus making them comprehensible to a broader community worldwide. By that we do not only imply scientific community but diving community as well.
Information about our teaching activities at University of Split School of Medicine are still kept in Croatian and presented on specialized web pages.
We sincerely hope that you will enjoy browsing through our web site. In case you wish to leave a feedback please do not hesitate and send an e-mail to our webmaster.

 

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